Sulfoximine-Directed Ruthenium-Catalyzed <i>ortho</i>-C–H Alkenylation of (Hetero)Arenes: Synthesis of EP3 Receptor Antagonist Analogue

Abstract

The reusable sulfox­imine directing-group-assisted Ru­(II)-catalyzed chemo- and regio­selective <i>ortho</i>-C–H alkenylation of arenes and hetero­arenes with acrylates and α,β-unsaturated ketones/vinyl sulfone is shown. The <i>N</i>-aroyl sulfoximine undergoes annulation with diphenyl­acetylene, delivering iso­quinoli­nones and methyl phenyl sulfoxide. The present protocol is successfully employed for the synthesis of the EP3 receptor antagonist analogue