Enantioselective Ruthenium(II)/Xyl-SunPhos/Daipen-Catalyzed
Hydrogenation of γ‑Ketoamides
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Abstract
A series of γ-hydroxy amides
were synthesized with high enantioselectivities
(up to 99%) using asymmetric hydrogenation of the corresponding γ-ketoamides
in the presence of Ru-Xyl-SunPhos-Daipen catalyst providing key building
blocks for a variety of naturally occurring and biologically active
compounds