Intermittent hypoxia decreases cell viability and impairs glutamate response.

Abstract

<p>Propidium iodide staining (A) and quantification of PI positive cells presented as mean <u>+</u> SD (B) of slices exposed to 7 days RA, SH or IH at baseline (BL), after 200 µM glutamate, and 10 mM glutamate, followed by a second 200 µM glutamate challenge. n = 12–18. *: At all concentrations RA^- < SH^- & IH^- (p<.001). ⁺ At 10mM: SH^- < IH^- (p<.05). ^# At 10 mM & 200 µM#2: BL < SH^- & IH^- (p<.05 and p<.001 respectively).</p