<i>In Vivo</i> Tracing Uptake and Elimination
of Organic Pesticides in Fish Muscle
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Abstract
Bioconcentration
factors (BCFs) measured in the laboratory are
important for characterizing the bioaccumulative properties of chemicals
entering the environment, especially the potential persistent organic
pollutants (POPs), which can pose serious adverse effects on ecosystem
and human health. Traditional lethal analysis methods are time-consuming
and sacrifice too many experimental animals. In the present study, <i>in vivo</i> solid-phase microextraction (SPME) was introduced
to trace the uptake and elimination processes of pesticides in living
fish. BCFs and elimination kinetic coefficients of the pesticides
were recorded therein. Moreover, the metabolism of fenthion was also
traced with <i>in vivo</i> SPME. The method was time-efficient
and laborsaving. Much fewer experimental animals were sacrificed during
the tracing. In general, this study opened up an opportunity to measure
BCFs cheaply in laboratories for the registering of emerging POPs
and inspecting of suspected POPs, as well as demonstrated the potential
application of <i>in vivo</i> SPME in the study of toxicokinetics
of pollutants