New Hydrogels
Based on Substituted Anhydride Modified
Collagen and 2‑Hydroxyethyl Methacrylate. Synthesis and Characterization
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Abstract
Semi-interpenetrated networks were
obtained by free radical polymerization/cross-linking
of substituted anhydride modified collagen with 2-hydroxyethyl methacrylate
(HEMA) in the presence of ammonium persulfate (APS) and <i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-tetramethyl ethylene diamine (TEMED). Substituted anhydride
modified collagens, porous materials with vinyl groups, have been
previously synthesized by reaction of soluble collagen with dimethyl
maleic anhydride (DMA) or citraconic anhydride (CTA). The structure
and physicochemical properties of the obtained hydrogels were investigated
by Fourier transform infrared spectroscopy, scanning electron microscopy
(SEM), and water retention studies. Thermal properties of substituted
anhydride modified collagen and their corresponding hydrogels have
been investigated by differential scanning calorimetry (DSC) in dried
and hydrated states. The denaturation temperature (<i>T</i><sub>d</sub>), denaturation enthalpy, and glass transition temperature
(<i>T</i><sub>g</sub>) have been determined, and they were
found to be dependent on chemical composition, thermal history, and
moisture content. The water states (free or bonded) in the hydrated
samples were correlated with their swelling degree