Abstract

<p>The enrichment score was defined as the mean of negative log-transformed Kolmogorov-Smirnov and Fisher P-values for over-representation of high-ranking GWAS SNPs among the eSNPs that affect the expression of the pathway member genes. The number in parentheses in the first column indicates the number of CAD-associated pathways (detailed in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004502#pgen.1004502.s004" target="_blank">Table S1</a>).</p><p>*FDR<20% in Stage 1 and 2 respectively, and FDR<5% in combined Stage 1 & 2.</p

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