Copper(II)-Catalyzed
Disulfide ScissionStepwise
Aerobic Oxidative Cleavage to Sulfinate and Sulfonate and Reductive
Anaerobic Cleavage to Thiols
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Abstract
The
Cu(II)-catalyzed oxidative and reductive cleavage of the disulfide
bond of <i>N</i>-(2-(2-(2-picolinamido)phenyl)disulfanyl)phenyl)picolinamide, <b>L</b>, is reported for the first time. Aerobic oxidation with
Cu(II) gives complete oxidation of S–S bond to sulfonates,
whereas Ag(I) gives only partial oxidation up to sulfinates, in the
absence of any other oxidizing agent, in tetrahydrofuran/water solution.
The <i>in situ</i> generated sulfonate product forms a thermally
stable, two-dimensional H-bonded polymeric complex with Cu(II) ions
in two polymorphic forms. <b>L</b> in the presence of Cu(II),
in an inert atmosphere, results in a reductive cleavage of the disulfide
bond and an <i>in situ</i> formation of a new C–S
bond. The latter forms a unique tetranuclear complex with Cu(II) employing
deprotonated amide groups and bridging thiol and chloride atoms. The
disulfide precursor and the products were characterized by X-ray crystallography
and spectroscopic techniques