Sensitivity of 5 human melanoma cell lines towards melphalan (L-PAM), dacarbazine (DIC), methotrexate (MTX), vinblastine (VBL), dactinomycin (DACT), doxorubicin (ADM), mitoxantrone (DHAQ), cisplatin (cDDP), and carboplatin (CDBCA) was tested by a standardized kinetic microassay. With respect to achievable plasma concns. in hyperthermic isolated limb perfusion VBL, DHAQ, ADM, DACT, and cDDP seem promising for further pharmacokinetically controlled in vivo-studies
