Interactions
between Anticancer <i>trans</i>-Platinum Compounds and Proteins:
Crystal Structures and ESI-MS Spectra
of Two Protein Adducts of <i>trans</i>-(Dimethylamino)(methylamino)dichloridoplatinum(II)
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Abstract
The adducts formed between <i>trans</i>-(dimethylamino)(methylamino)dichloridoplatinum(II),
[t-PtCl<sub>2</sub>(dma)(ma)], and two model proteins, i.e., hen egg
white lysozyme and bovine pancreatic ribonuclease, were independently
characterized by X-ray crystallography and electrospray ionization
mass spectrometry. In these adducts, the Pt<sup>II</sup> center, upon
chloride release, coordinates either to histidine or aspartic acid
residues while both alkylamino ligands remain bound to the metal.
Comparison with the cisplatin derivatives of the same proteins highlights
for [t-PtCl<sub>2</sub>(dma)(ma)] a kind of biomolecular metalation
remarkably different from that of cisplatin