High serum amyloid A protein and organomegaly in KCASP1Tg and KIL-18Tg(+) mice.

Abstract

<p><b>A</b>) Serum amyloid A protein (SAA) levels were significantly higher in KCASP1Tg mice than in normal control and 6-months old KIL-18Tg(−) mice. Eighteen-months old KIL-18Tg(+) mice also showed elevated SAA concentration (n = at least 7). <b>B</b>) <b>C</b>) The liver, kidney, and spleen of both KCASP1Tg and KIL-18Tg(+) mice were significantly enlarged compared to control and KIL-18Tg(−) mice.</p