<p>Differences in PI3K/AKT, Ras/Raf/MEK/ERK and JAK/Stat3 signalling between fswt/fs188 and fs164/fs120 cells are shown. Upregulation/downregulation of activities or levels of expression of individual proteins are indicated by up or down arrows. VEGF188 expression is associated with reduced proliferation rates, increased apoptosis and typical integrin-dependent mesenchymal morphology and migration mode. VEGF164/VEGF120 expression is associated with faster proliferation rates, increased survival and rounded/amoeboid integrin-independent morphology and mode of motility. Migration of fs164/fs120 but not fswt/fs188 cells is contractility-dependent.</p
