Enantioselective Synthesis
of (+)-Penostatin E
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Abstract
The
first enantioselective total synthesis of penostatin E has
been accomplished. Two highly efficient and diastereoselective reactions,
a Hosomi–Sakurai allylation and an intramolecular Pauson–Khand
reaction, were utilized for the construction of the basic carbon framework
of the target molecule as the key steps. A late-stage introduction
of the side chain and a successful base-promoted elimination reaction
afforded an efficient synthetic route to (+)-penostatin E