Enantioselective
C–H Bond Addition of Pyridines
to Alkenes Catalyzed by Chiral Half-Sandwich Rare-Earth Complexes
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Abstract
Cationic half-sandwich scandium alkyl
complexes bearing monocyclopentadienyl
ligands embedded in chiral binaphthyl backbones act as excellent catalysts
for the enantioselective C–H bond addition of pyridines to
various 1-alkenes, leading to formation of a variety of enantioenriched
alkylated pyridine derivatives in high yields and excellent enantioselectivity
(up to 98:2 er)