Rh(II)/Brønsted Acid Cocatalyzed Intramolecular Trapping of Ammonium Ylides with Enones: Diastereoselective Synthesis of 2,2,3-Trisubstituted Indolines

Abstract

Highly diastereoselective intramolecular trapping of ammonium ylides with enones has been developed through a Rh­(II)/Brønsted acid cocatalytic strategy. This process allows rapid and efficient construction of <i>N</i>-unprotected polyfunctional 2,2,3-trisubstituted indolines in moderate to good yields with excellent diastereoselectivity