Sequential Allylic Substitution/Pauson–Khand
Reaction: A Strategy to Bicyclic Fused Cyclopentenones from MBH-Acetates
of Acetylenic Aldehydes
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Abstract
An
efficient approach for the construction of novel bicyclic fused
cyclopentenones starting from Morita–Baylis–Hillman
(MBH) acetates of acetylenic aldehydes with flexible scaffold diversity
has been achieved using a two-step reaction sequence involving allylic
substitution and the Pauson–Khand reaction. This strategy provided
a facile access to various bicyclic cyclopentenones fused with either
a carbocyclic or a heterocyclic ring system in good yield