Rapid Access to Novel 1,2,3-Triazolo-Heterocyclic
Scaffolds via Tandem Knoevenagel Condensation/Azide–Alkyne
1,3-Dipolar Cycloaddition Reaction in One Pot
- Publication date
- Publisher
Abstract
An
operationally simple, one-pot, two-step cascade method has been
developed to afford biologically important fused 1,2,3-triazolo-heterocyclic
scaffolds from 2-alkynyl aryl(heteroaryl) aldehydes and phenacyl azides.
This unique atom economical transformation engages four reactive centers
(aldehyde, alkyne, active methylene, and azide) under metal-free catalysis