Na<sub>2</sub>S-mediated thionation: an efficient access to secondary and tertiary α-ketothioamides via Willgerodt–Kindler reaction of readily available arylglyoxals with amines

Abstract

<div><p>The task of this paper is to provide an efficient process for synthesis of secondary and tertiary α-ketothioamides via Willgerodt–Kindler reaction of readily available arylglyoxals with amines using Na<sub>2</sub>S as an effective catalyst. A plausible role for Na<sub>2</sub>S in the reaction of arylglyoxals with primary amines is proposed.</p></div

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