<p>RANK-L and OPG mRNA levels were evaluated by real-time PCR as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107224#s2" target="_blank">Materials and Methods</a>. Messenger expression was normalized on G3PDH internal control and displayed as fold increase over Te85 wt reference sample. (A): RANK-L mRNA expression (B): OPG mRNA expression. Data are shown as mean ± SE, N = 12, ***p<0.001 versus Te85 wt. (C): Mineralization by Te85 clones was assessed over a 21 days period as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107224#s2" target="_blank">Materials and Methods</a>. (A): Quantification of the amount of alizarin red S staining of each clone. Data are shown as means ± SE (N = 6) analysed by Kruskal-Wallace test with Dunn's multiple comparison post-test. ***<i>P</i><0.001 versus Te85 wt and Te85-P2X7RA; *<i>P</i><0.05 vs Te85 wt; <sup></sup><i>P</i><0.01 versus Te85 P2X7RA. Colour coding: green Te85 wt, red Te85 P2X7RA, cyan Te85 P2X7RB, purple Te85 P2X7RA+B.</p
