Influence of mutations affecting acetate metabolism on the growth advantage of <i>rpoB</i> P564L and Δ<i>rpoS</i> mutants.

Abstract

<p>Fold increase in wild-type and mutant cells added to 24 h wild-type colonies and allowed to age for a further 7 days, as a function of acetate metabolism activity. <b>A</b>. Relative to the <i>rpoB</i> 564L mutant. <b>B</b>. Relative to the Δ<i>rpoS</i> mutant. The box plots show the first quartile, median, and third quartile values. Outliers are indicated as triangles. Δ<i>apa</i> indicates deletion of the three genes, <i>ackA-pta</i> and <i>acs</i>. Statistical significance of differences, compared to the <i>rpoB</i> or <i>rpoS</i> mutants, is given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0109255#pone.0109255.s002" target="_blank">Table S2</a> and is indicated in the figure by asterisks (**  = 99% confidence interval, ***  = 99.9% confidence interval).</p