Copper-Free Direct C–H Trifluoromethylation of Acetanilides with Sodium Trifluoromethanesulfinate

Abstract

A copper-free direct C–H ortho trifluoromethylation of electron-deficient 4-substituted acetanilides using Langlois reagent (NaSO₂CF₃) as the CF₃ source in the presence of <i>tert</i>-butyl hydroperoxide (<i>t</i>BuOOH, TBHP) was developed