Copper-Catalyzed Cascade Transformation of <i>O</i>‑Propargylic Oximes with Sulfonyl Azides to α,β-Unsaturated <i>N</i>‑Acylamidines

Abstract

Copper-catalyzed cascade transformations of <i>O-</i>propargylic oximes and sulfonyl azides were carried out to efficiently afford α,β-unsaturated <i>N</i>-acylamidines. The reaction involved the intramolecular attack of the oxime group to the ketenimine moiety that was generated in situ, followed by the cleavage of the N–O bond