1<p>For these values ( = 4, <i>r<sub>i</sub></i> = 100) we get ∼100% for the fraction of surface area lost via vesiculation.</p>2<p>Vesicle [Hb] is that of the shedding cell, which is later referred to as model 1.</p><p>We assume a vesicle radius of 100 nm (the 90th percentile).</p><p>Estimated fraction of volume and Hb lost (mean ± std) by vesiculation as a fraction of total volume or Hb lost during maturation.</p