<p>(A) Genetic interactions identified between EMC genes and <i>CHO2</i>. Plotted is the ratio of spot size of the single EMC mutants versus the corresponding double mutants with <i>Δcho2</i> in the absence and presence of choline. The data used to generate this graph are in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001969#pbio.1001969.s007" target="_blank">Table S1</a>. (B) EMC gene cluster identified in the global genetic interaction map <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001969#pbio.1001969-Costanzo1" target="_blank">[34]</a> and aggravating genetic interactions with a cluster of genes that function in the methylation pathway of phospholipid synthesis. Aggravating interactions have negative values, and alleviating interactions have positive values. Trees identify isolated clusters identified in the global genetic interaction map. The data used to generate this figure have been published <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001969#pbio.1001969-Costanzo1" target="_blank">[34]</a>. (C) Functional map for <i>EMC6</i> derived using genetic interactions identified in the <i>EMC6</i> SGA screen. Colored nodes represent functional groups, and edges define associations between groups. Node size and edge thickness indicate their level of significance within the network. Genes (grey nodes) identified in the screen that are associated with each functional group are shown (blue edges).</p
