Curvulamine, a New Antibacterial Alkaloid Incorporating Two Undescribed Units from a <i>Curvularia</i> Species

Abstract

The white croaker (<i>Argyrosomus argentatus</i>) derived <i>Curvularia</i> sp. IFB-Z10 produces curvulamine as a skeletally unprecedented alkaloid incorporating two undescribed extender units. Curvulamine is more selectively antibacterial than tinidazole and biosynthetically unique in the new extenders formed through a decarboxylative condensation between an oligoketide motif and alanine