Pd-Catalyzed Intramolecular Aerobic Oxidative C–H
Amination of 2‑Aryl-3-(arylamino)quinazolinones: Synthesis
of Fluorescent Indazolo[3,2‑<i>b</i>]quinazolinones
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Abstract
A palladium-catalyzed
intramolecular aerobic oxidative C–H
amination of 2-aryl-3-(arylamino)quinazolinones has been developed,
providing a variety of substituted indazolo[3,2-<i>b</i>]quinazolinone derivatives in moderate to excellent yields.
Preliminary mechanistic studies suggested that a palladacycle dimer
could be the key intermediate, which underwent a cascade “rollover”
cyclometalation and C–H amination sequence. Furthermore, the
potential utility of these products has been demonstrated as a new
class of blue fluorophores for fluorescent materials