Aliphatic Dicarboxylate Directed Assembly of Silver(I)
1,3,5-Triaza-7-phosphaadamantane Coordination Networks: Topological
Versatility and Antimicrobial Activity
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Abstract
The
present work describes the facile synthesis, full characterization,
and architectural diversity of three new bioactive silver-organic
networks, namely 1D [Ag<sub>2</sub>(μ-PTA)<sub>2</sub>(<i>μ-</i>suc)]<sub><i>n</i></sub>·2<i>n</i>H<sub>2</sub>O (<b>1</b>), 2D [Ag<sub>2</sub>(μ-PTA)<sub>2</sub>(μ<sub>4</sub><i>-</i>adip)]<sub><i>n</i></sub>·2<i>n</i>H<sub>2</sub>O (<b>2</b>), and
3D [Ag<sub>2</sub>(μ<sub>4</sub>-PTA)(μ<sub>4</sub><i>-</i>mal)]<sub><i>n</i></sub> (<b>3</b>) coordination
polymers, generated via a mixed-ligand strategy using PTA (1,3,5-triaza-7-phosphaadamantane)
as a main building block and flexible aliphatic dicarboxylic acids
(succinic (H<sub>2</sub>suc), adipic (H<sub>2</sub>adip), or malonic
(H<sub>2</sub>mal) acids) as an ancillary ligand source. The compounds <b>1</b>–<b>3</b> were isolated as moderately air and
light stable crystalline solids and were fully characterized by IR
and <sup>1</sup>H and <sup>31</sup>P{<sup>1</sup>H} NMR spectroscopy,
elemental analysis, ESI(±)-MS spectrometry, and single-crystal
X-ray crystallography. The type of aliphatic dicarboxylate plays a
key role in defining the dimensionality and structural and topological
features of the resulting networks, which are also driven by the PTA
blocks that adopt unconventional N,P- or N<sub>3</sub>,P-coordination
modes. The topological analysis of simplified underlying nets revealed
that <b>1</b> possesses uninodal 3-connected chains with the
SP 1-periodic net (4,4)(0,2) topology, <b>2</b> features a uninodal
4-connected layer with the skl topology, and <b>3</b> reveals
a uninodal 4-connected metal–organic framework with the dia
topology. The presence of the crystallization water molecules in polymers <b>1</b> and <b>2</b> gives rise to the extension of their
metal–organic structures into 3D (<b>1</b>) or 2D (<b>2</b>) H-bonded networks that disclose rather rare topologies.
All of the obtained silver(I) coordination polymers feature solubility
in water (<i>S</i><sub>25 °C</sub> ≈ 3–5
mg mL<sup>–1</sup>) and show significant antibacterial and
antifungal activity against the selected strains of Gram-negative
(Escherichia coli, Pseudomonas
aeruginosa) and Gram-positive (Staphylococcus
aureus) bacteria and yeast (Candida
albicans)