A new natural nucleotide and other antibacterial metabolites from an endophytic <i>Nocardia</i> sp.

Abstract

<div><p>Nine compounds were isolated from <i>Nocardia</i> sp. YIM 64630, and their structures were elucidated as 5′-<i>O</i>-acetyl-2′-deoxyuridine (<b>1</b>), 22<i>E</i>,24<i>R</i>-5α,6α-epoxyergosta-8(14),22-diene-3β,7α-diol (<b>2</b>), 22<i>E</i>,24<i>R</i>-5α,6α-epoxyergosta-8,22-diene-3β,7α-diol (<b>3</b>), 22<i>E</i>,24<i>R</i>-ergosta-7,22-diene-3β,5α,6β-triol (<b>4</b>), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (<b>5</b>), 4′,5,6-trihydroxy-7-methoxyisoflavone (<b>6</b>), 2,4,4′-trihydroxy-deoxybenzoin (<b>7</b>), methyl [4-hydroxyphenyl]acetate (<b>8</b>) and daidzein by extensive spectroscopic analyses. Compound <b>1</b> was isolated from natural resources for the first time. The antimicrobial and antioxidant activities of compounds <b>1</b>–<b>8</b> were investigated.</p></div

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