I<sub>2</sub>‑Mediated
Oxidative Cyclization
for Synthesis of Substituted Indolizines
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Abstract
A direct
method for the synthesis of substituted indolizines by
means of I<sub>2</sub>-mediated oxidative tandem cyclization via C–N/C–C
bond formation was developed. Various substituted aromatic/aliphatic
enolizable aldehydes and 2-pyridylacetates/acetonitrile/acetone proceeded
smoothly in this transformation, and the desired products were generated
in moderate to good yields