Diastereoselective Synthesis
of Functionalized Spirocyclopropyl
Oxindoles via P(NMe<sub>2</sub>)<sub>3</sub>‑Mediated Reductive Cyclopropanation
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Abstract
A P(NMe<sub>2</sub>)<sub>3</sub>-mediated reductive cyclopropanation
reaction of α-keto esters or amides with isatin-derived alkenes
has been developed, providing efficient and diastereoselective synthesis
of highly functionalized spirocyclopropyl oxindoles bearing two all-carbon
quaternary centers. This reaction also represents a complementary
and nonmetal-involving protocol for the challenging cyclopropanation
of electron-deficient alkenes