Flow Update for the Carbonylation of 1‑Silyl-Substituted
Organolithiums under CO Pressure
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Abstract
The
generation of, and subsequent reactions with, 1-silyl-substituted
organolithiums with CO was carried out using serially connected flow
microreactors. The flow system proved to be quite useful for the carbonylation
of silyl-substituted organolithiums under slightly pressurized conditions
of CO, which was created conveniently by the use of a back-pressure
regulator. This flow system, coupled with heating, accelerated the
carbonylation reaction of 1-silyl-substituted organolithiums and allowed
the stable silyl-substituted alkyllithium, 1,3-disilylallyllithium,
which was not effective in a batch-flask reaction under a CO atmosphere,
to participate in an efficient carbonylation reaction