<p><b>A–B:</b> AGS-G<sub>R</sub> cells (<b>A</b>) and MKN45 cells (<b>B</b>) were treated with gastrin, and phospho-LKB1 (Ser-428) protein levels determined by Western blot. The phospho-LKB1 bands from a representative experiment are shown. <b>C–D:</b> AGS-G<sub>R</sub> cells (<b>C</b>) and MKN45 (<b>D</b>) were treated with gastrin, and phospho-SIK1 (Thr-182) protein levels determined by Western blot. The phospho-SIK1 bands from a representative experiment are shown. <b>E:</b> AGS-G<sub>R</sub> cells transfected with siSIK1 or siCtr and real-time cell migration monitored (0–24 h). Results show one representative of three independent experiments (mean ±SD of three technical replicates). <b>F:</b> MMP-9 mRNA expression in cells transfected with pSIK1 and treated with gastrin. Results show one representative of three independent experiments, (mean ± SD).</p
