Palladium-Catalyzed Cross-Coupling of Benzyl Chlorides
with Cyclopropanol-Derived Ketone Homoenolates
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Abstract
The
palladium-catalyzed cross-coupling reaction of cyclopropanol-derived
ketone homoenolates with benzyl chlorides is reported. This reaction
proceeds in high yields with electron-neutral and electron-rich benzyl
chlorides; however, yields are low with electron-poor benzyl chlorides.
In addition, a range of cyclopropanols can be coupled in good yields.
The reaction can be conducted with a low catalyst loading (1% Pd)
and on a gram scale without reduction in yield