Metal-Free Synthesis of Oxindoles
via (NH<sub>4</sub>)<sub>2</sub>S<sub>2</sub>O<sub>8</sub>‑Mediated
Halocarbocyclization
of Alkenes in Water
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Abstract
A metal-free
synthesis of oxindoles was achieved through the (NH<sub>4</sub>)<sub>2</sub>S<sub>2</sub>O<sub>8</sub>-mediated halocarbocyclization
of alkenes. This protocol provides a practical and environmentally
benign method for the construction of halo-containing oxindoles in
water. The advantages of this reaction are its good functional group
tolerance and mild reaction conditions. On the basis of experimental
observations, a plausible reaction mechanism is proposed
