Rhodium(III)-Catalyzed Olefinic C–H Alkynylation of Acrylamides Using Tosyl-Imide as Directing Group

Abstract

The Rh­(III)-catalyzed C–H alkynylation of acrylamide derivative is realized using a hypervalent alkynyl iodine reagent. The use of a weakly coordinating directing group proved to be of critical importance. This reaction displays broad functional group tolerance and high efficiency, which opens a new synthetic pathway to access functionalized 1,3-enyne skeletons