3D-Printed Paper Spray Ionization Cartridge with Fast
Wetting and Continuous Solvent Supply Features
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Abstract
We
report the development of a 3D-printed cartridge for paper spray
ionization (PSI) that can be used almost immediately after solvent
introduction in a dedicated reservoir and allows prolonged spray generation
from a paper tip. The fast wetting feature described in this work
is based on capillary action through paper and movement of fluid between
paper and the cartridge material (polylactic acid, PLA). The influence
of solvent composition, PLA conditioning of the cartridge with isopropanol,
and solvent volume introduced into the reservoir have been investigated
with relation to wetting time and the amount of solvent consumed for
wetting. Spray has been demonstrated with this cartridge for tens
of minutes, without any external pumping. It is shown that fast wetting
and spray generation can easily be achieved using a number of solvent
mixtures commonly used for PSI. The PSI cartridge was applied to the
analysis of lidocaine from a paper tip using different solvent mixtures,
and to the analysis of lidocaine from a serum sample. Finally, a demonstration
of online paper chromatography–mass spectrometry is given