Multi-State
Regulation of the Dihydrogen Phosphate
Binding Affinity to a Light- and Heat-Responsive Bis-Urea Receptor
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Abstract
A responsive
bis-urea receptor can be switched between three isomers
using light and heat as evidenced by <sup>1</sup>H NMR and UV–vis
spectroscopy. Anion binding experiments (<sup>1</sup>H NMR titrations,
ESI-MS) reveal a high selectivity for dihydrogen phosphate. Importantly,
a large difference in binding affinity to the interchangeable isomers
is observed, which is further rationalized by DFT calculations. As
a consequence, the amount of bound substrate can be controlled via
photo- and thermal isomerization in a three-step process