Synthesis of isoquinolinones 7a–g.

Abstract

<p>a) MeNH₂, THF, r.t., ∼75%; b) DIC, <b>2</b>, CH₂Cl₂, r.t., 84–91%; c) Ac₂O, reflux, ∼100%; d) TsOH, toluene, heat, 71% for two steps; e) RX, K₂CO₃, DMF, r.t., ∼95%.</p