Synthesis of isoquinolinones 7a–g.
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Abstract
<p>a) MeNH<sub>2</sub>, THF, r.t., ∼75%; b) DIC, <b>2</b>, CH<sub>2</sub>Cl<sub>2</sub>, r.t., 84–91%; c) Ac<sub>2</sub>O, reflux, ∼100%; d) TsOH, toluene, heat, 71% for two steps; e) RX, K<sub>2</sub>CO<sub>3</sub>, DMF, r.t., ∼95%.</p