Recognition
Characteristics of an Adaptive Vesicular
Assembly of Amphiphilic Baskets for Selective Detection and Mitigation
of Toxic Nerve Agents
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Abstract
We used isothermal
titration calorimetry to investigate the affinity
of basket <b>1</b> (470 Å<sup>3</sup>) for trapping variously
sized and shaped organophosphonates (OPs) <b>2</b>–<b>12</b> (137–244 Å<sup>3</sup>) in water at 298.0 K.
The encapsulation is, in each case, driven by favorable entropy (<i>T</i>Δ<i>S</i>° = 2.9 kcal/mol), while
the enthalpic component stays small and in some cases endothermic
(Δ<i>H</i>° ≥ −1 kcal/mol). Presumably,
a desolvation of basket <b>1</b> and OP guests permits the inclusion
complexation at room temperature via a “classical” hydrophobic
effect. The amphiphilic basket <b>1</b> shows a greater affinity
(Δ<i>G</i>° ≈ −5 to −6 kcal/mol),
both experimentally and computationally, for encapsulating larger
organophosphonates whose size and shape correspond to VX-type agents
(289 A<sup>3</sup>). Importantly, baskets assemble into a vesicular
nanomaterial (<i>D</i><sub>H</sub> ≈ 350 nm) that
in the presence of neutral OP compounds undergoes a phase transition
to give nanoparticles (<i>D</i><sub>H</sub> ≈ 250
nm). Upon the addition of an anionic guest to basket <b>1</b>, however, there was no formation of nanoparticles and the vesicles
grew into larger vesicles (<i>D</i><sub>H</sub> ≈
750 nm). The interconversion of the different nanostructures is reversible
and, moreover, a function of the organophosphonate present in solution.
On the basis of <sup>1</sup>H NMR spectroscopic data, we deduced that
neutral guests insert deep into the basket’s cavity to change
its shape and thereby promote the conversion of vesicles into nanoparticles.
On the contrary, the anionic guests reside at the northern portion
of the host to slightly affect its shape and geometric properties,
thereby resulting in the vesicles merely transforming into larger
vesicles