Iron-Mediated Carboarylation/Cyclization of Propargylanilines
with Acetals: A Concise Route to Indeno[2,1‑<i>c</i>]quinolines
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Abstract
FeCl<sub>3</sub>- and FeBr<sub>3</sub>-mediated tandem carboarylation/cyclization
of propargylanilines with diethyl benzaldehyde acetals furnished the
tetracyclic core of indeno[2,1-<i>c</i>]quinolines. 5-Tosyl-6,7-dihydro-5<i>H</i>-indeno[2,1-<i>c</i>]quinoline and 7<i>H</i>-indeno[2,1-<i>c</i>]quinoline derivatives were obtained
in good to excellent yields, respectively, by tuning the FeX<sub>3</sub> loadings and/or reaction temperatures
