<p>Group average change from initial body weight (top panels) and neurological disease severity score (bottom panels) are compared over time from age at study start to age 180 days. Left panels show data from all animals (All); middle and right panels show data from females (F) and males (M), respectively. Vehicle control (CTRL) animals received 0.22 micron filtered animal facility drinking water. Dexpramipexole-treated (DRUG) animals received daily 200 mg/kg/day dexpramipexole (1.19 g/L) in filtered drinking water. Because animals died at different ages, group means were computed after carrying forward last values for each animal through 180 days of age. Results of statistical analysis for summary measures taken from these data are given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0091608#pone-0091608-t002" target="_blank">Table 2</a>.</p