Jiangrines A–F and Jiangolide from an Actinobacterium, <i>Jiangella gansuensis</i>

Abstract

Seven new compounds, including five pyrrol-2-aldehyde derivatives, jiangrines A–E (<b>1</b>–<b>5</b>), one indolizine derivative, jiangrine F (<b>7</b>), and one glycolipid, jiangolide (<b>8</b>), along with a known compound, pyrrolezanthine (<b>6</b>), were isolated from the fermentation broth of <i>Jiangella gansuensis</i>, an actinobacterium assigned to a novel family, Jiangellaceae, and a novel order, Jiangellales. The structures were elucidated by detailed spectroscopic analysis and through chemical methods. Compounds <b>1</b>, <b>2</b>, <b>3</b>/<b>4</b>, <b>5</b>, <b>6</b>, and <b>8</b> demonstrated inhibitory effects on lipopolysaccharide-induced NO production in RAW 264.7 macrophage cells, with IC₅₀ values of 97.8, 60.7, 30.1, 54.9, 58.8, and 61.4 μM, respectively