Enhanced Schwann Cell Attachment and Alignment Using
One-Pot “Dual Click” GRGDS and YIGSR Derivatized Nanofibers
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Abstract
Using
metal-free click chemistry and oxime condensation methodologies,
GRGDS and YIGSR peptides were coupled to random and aligned degradable
nanofiber networks postelectrospinning in a one-pot reaction. The
bound peptides are bioactive, as demonstrated by Schwann cell attachment
and proliferation, and the inclusion of YIGSR with GRGDS alters the
expression of the receptor for YIGSR. Additionally, aligned nanofibers
act as a potential guidance cue by increasing the aspect ratio and
aligning the actin filaments, which suggest that peptide-functionalized
scaffolds would be useful to direct SCs for peripheral nerve regeneration