Adhesion Properties of Catechol-Based Biodegradable
Amino Acid-Based Poly(ester urea) Copolymers Inspired from Mussel
Proteins
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Abstract
Amino acid-based poly(ester urea)
(PEU) copolymers functionalized
with pendant catechol groups that address the need for strongly adhesive
yet degradable biomaterials have been developed. Lap-shear tests with
aluminum adherends demonstrated that these polymers have lap-shear
adhesion strengths near 1 MPa. An increase in lap-shear adhesive strength
to 2.4 MPa was achieved upon the addition of an oxidative cross-linker.
The adhesive strength on porcine skin adherends was comparable with
commercial fibrin glue. Interfacial energies of the polymeric materials
were investigated via contact angle measurements and Johnson–Kendall–Roberts
(JKR) technique. The JKR work of adhesion was consistent with contact
angle measurements. The chemical and physical properties of PEUs can
be controlled using different diols and amino acids, making the polymers
candidates for the development of biological glues for use in clinical
applications