Preparation and Size Control of Sub-100 nm Pure Nanodrugs
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Abstract
Pure nanodrugs (PNDs), nanoparticles
consisting entirely of drug
molecules, have been considered as promising candidates for next-generation
nanodrugs. However, the traditional preparation method via reprecipitation
faces critical challenges including low production rates, relatively
large particle sizes, and batch-to-batch variations. Here, for the
first time, we successfully developed a novel, versatile, and controllable
strategy for preparing PNDs via an anodized aluminum oxide (AAO) template-assisted
method. With this approach, we prepared PNDs of an anticancer drug
(VM-26) with precisely controlled sizes reaching the sub-20 nm range.
This template-assisted approach has much higher feasibility for mass
production comparing to the conventional reprecipitation method and
is beneficial for future clinical translation. The present method
is further demonstrated to be easily applicable for a wide range of
hydrophobic biomolecules without the need of custom molecular modifications
and can be extended for preparing all-in-one nanostructures with different
functional agents