<p>A) Protein alignments of human (h), rat (r), and mouse (m) Bex proteins as determined using CLUSTAL-W2 software. Conserved residues are highlighted in colors. The accession number of the Bex protein sequences analyzed in human (h), mouse (m) and rat (r) are hBex1 (NP_060946.3), hBex2 (NP_116010.1), hBex3 (AAX40680.1), hBex4 (NP_001121160.1), hBex5 (NP_001153032.1), mBEX1 (NP_033078.2), mBEX2 (NP_033879.1), mBEX3 (NP_001103703.1), mBex4 (NP_997622.1), mBex6 (NP_001028711.1), rBex1(NP_001032442.1), rBex2 (NP_001070903.1), rBex3 (NP_445853.1) and rBex4 (XP_003754868.1). Histidine and asparagine-rich regions (NH-stretch), the RRxRxR motif and the CLxP motif are highlighted. B) Phylogenetic tree derived from the alignment sequence. Bex proteins are classified into three different subgroups. C) Conserved gene structure of all Bex proteins. The ORF coding region is located in the third exon (red).</p
