Cocrystallization of Nutraceuticals
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Abstract
Cocrystallization
has emerged over the past decade as an attractive
technique for modification of the physicochemical properties of compounds
used as active pharmaceutical ingredients (APIs), complementing more
traditional methods such as salt formation. Nutraceuticals, with associated
health benefits and/or medicinal properties, are attractive as coformers
due to their ready availability, known pharmacological profile, and
natural origin, in addition to offering a dual therapy approach. Successful
studies of favorably altering the physicochemical properties of APIs
through cocrystallization with nutraceuticals are highlighted in this
review. Many of the key functional groups commonly seen in nutraceuticals
(e.g., acids, phenols) underpin robust supramolecular synthons in
crystal engineering. This review assesses the structural data available
to date across a diverse range of nutraceuticals, both in pure form
and in multicomponent materials, and identifies the persistent supramolecular
features present. This insight will ultimately enable predictive and
controlled assembly of functional materials incorporating nutraceuticals
together with APIs