General and Chemoselective Bisphosphonylation of Secondary
and Tertiary Amides
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Abstract
With
Tf<sub>2</sub>O as the activation reagent, a mild and general
method has been developed for the bisphosphonylation of both secondary
and tertiary amides. The protocol is highly efficient and chemoselective,
and it tolerates a number of sensitive functional groups such as cyano,
ester, and aldehyde groups