6‑(Bromomaleimido)hexanoic Acid as a Connector
for the Construction of Multiple Branched Peptide Platforms
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Abstract
We
report on a novel and user-friendly platform based on a bromomaleimide
moiety to obtain branched peptides. The platform is stable for all
SPPS conditions. The bromomaleimide core was conjugated to <i>n</i>-copies of thiol–peptide in-solution to obtain two/four/eight-armed
dendrimers. Using ‘<i>n</i>’ number of bromomaleimide
analogues, 2<sup><i>n</i></sup> ligands were incorporated
at both bromo and ene positions via a thioether bond. This method
has the advantage of high conversion in a short time, thus enabling
effortless purification and characterization processes