Mohangamides A and B, New Dilactone-Tethered Pseudo-Dimeric
Peptides Inhibiting <i>Candida albicans</i> Isocitrate Lyase
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Abstract
Mohangamides A and
B (<b>1</b>–<b>2</b>) were
discovered from a marine <i>Streptomyces</i> sp. collected
in an intertidal mud flat. The structures of the compounds were elucidated
as novel dilactone-tethered pseudodimeric peptides bearing two unusual
acyl chains and 14 amino acid residues based on comprehensive spectroscopic
analysis. The absolute configurations of the mohangamides were determined
by chemical derivatizations, followed by chromatographic and spectroscopic
analyses. Mohangamide A displayed strong inhibitory activity against <i>Candida albicans</i> isocitrate lyase