Silica Nanotubes Decorated by pH-Responsive Diblock Copolymers for Controlled Drug Release

Abstract

A novel nanocontainer, which has silica nanotube (SNT) core and pH-sensitive polymer shell attaching on the exterior surface of silica nanotube, is presented in this paper. Polymer nanorods, which are conveniently fabricated though polymerization-induced self-assembly and reorganization method, are used as templates for the deposition of silica to fabricate hybrid nanorods. Calcination of as-synthesized silica hybrid nanorods leads to hollow SNTs. SNTs are functionalized with reversible addition–fragmentation chain transfer (RAFT) agent, then surface RAFT polymerization is conducted to get poly­(2-(diethylamino)­ethyl methacrylate)-<i>b</i>-poly­(oligo­(ethylene glycol) methacrylate)-coated SNTs (SNT-PDEAEMA-<i>b</i>-POEGMA). Doxorubicin (DOX) can be encapsulated in SNT-PDEAEMA-<i>b</i>-POEGMA, and controlled release of loaded DOX is achieved by adjusting pH of the medium. In vitro cell viability and cellular internalization study confirm the potential application of this nanocontainer in drug and gene delivery